“Nothing in biology makes sense except in the light of evolution. ” — Theodosius Dobzhansky
Ph.D. – Colorado State University, 1997
B.S. – Creighton University, 1992
2500 California Plaza
Omaha, NE 68178-0103
Office: Hixson-Lied 423
Lab: Rigge Science 326
Our research focuses on studying the cellular interactions between the nervous system and the immune system during development, following injury, and regulating repair. Areas of focus include: central nervous system immune responses following injury, intracellular signaling and epigenetic mechanisms underlying immune and nervous system interactions during development and following injury, and cellular effects of antiretroviral nanoparticles on immune cell and nervous system cell physiology.
Zheng J., D. Niemann, M. S. Bauer, A. L. Lopez, D. A. Erichsen, L. A. Ryan,
L. Gendelman, A. Shibata and H. E. Gendelman. The regulation of neurotrophic
factor activities during HIV-1 infection and immune activation of mononuclear
phagocytes. (Submitted to Neurotoxicity Research)
Destache, C. J., T. Belgum, K. Christensen, A. Shibata, A. Sharma and A. Dash. 2009. Combination antiretroviral drugs in PLGA nanoparticle for HIV-1. BMC Infectious Diseases 9: ARTN 198.
Shibata, A., M. Zelivyanskaya, J. Limoges, K. A. Carlson, S. Gorantla, C. Branecki, S. Bishu, H. G. Xiong and H. E. Gendelman. 2003. Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function. Journal of Neuroimmunology 142: 112-129.
Shibata A., C. E. Laurent and T. E. Smithgall. 2003. The c-Fes protein-tyrosine kinase accelerates NGF-induced differentiation of PC12 cells through a PI3K-dependent mechanism. Cellular Signaling 15: 279-288.
Ahmad, I., H. R. Acharya, J. A. Rogers, A. Shibata, T. E. Smithgall and C. M. Dooley. 1998. The role of NeuroD as a differentiation factor in the mammalian retina. Journal of Molecular Neuroscience 11: 165-178.
Smithgall, T. E., J. A. Rogers, K. L. Peters, J. Z. Li, S. D. Briggs, J. M. Lionberger, H. Y. Cheng, A. Shibata, B. Scholtz, S. Schreiner and N. Dunham. 1998. The c-Fes family of protein-tyrosine kinases. Critical Reviews in Oncogenesis 9: 43-62.
Shibata, A., M. V. Wright, S. David, L. McKerracher, P. E. Braun and S. B. Kater. 1998. Unique responses of differentiating neuronal growth cones to inhibitory cues presented by oligodendrocytes. Journal of Cell Biology 142: 191-202.
Li, M., A. Shibata, C. M. Li, P. E. Braun, L. McKerracher, J. Roder, S. B. Kater and S. David. 1996. Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. Journal of Neuroscience Research 46: 404-414.
Kater S. and A. Shibata. 1994. The unique and shared properties of neuronal growth cones that enable navigation and specific pathfinding. Journal of Physiology (Paris) 88: 155-163.
Fliege R., S. Tong, A. Shibata, K. W. Nickerson and T. Conway. 1992. The Enter Doudoroff pathway in Escherichia coli is induced for oxidative glucose metabolism via pyrroloquinoline quinone-dependent glucose dehydrogenase. Applied and Environmental Microbiology 58: 3826-3829.
Egan S. E., R. Fliege, S. Tong, A. Shibata, R. E. Wolf and T. Conway. 1992. Molecular characterization of the Enter Doudoroff pathway in Escherichia coli: Sequence analysis and localization of promoters for the edd-eda operon. Journal of Bacteriology 174: 4638-4616.