Mark V. ReedyAssociate ProfessorCell and Developmental Biology Postdoctoral fellow, M.D. Anderson Cancer Center, 1998-2001
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Courses Offered
- BIO 362 - Cell Structure and Function - Fall semester
- BIO 467 - Developmental Biology (Embryology) - Spring semester
- BIO 532 - Current Topics in Cellular and Molecular Biology (with Dr. Austerberry) - Spring semester
Research Interests
I am interested in the embryonic mechanisms that establish the final arrangement of cells and tissues in adult organisms. This phenomenon, called pattern formation, is driven by two developmental events: cell differentiation and morphogenesis. Differentiation refers to the molecular and functional diversification of cell types, whereas morphogenesis describes the physical movements that cells and tissues undergo as they assemble into their final biological forms. I am studying these processes in two model systems, the developing limb and neural crest cells.Recent Publications:
M.V. Reedy, D. M. Parichy, C. A. Erickson, K. A. Mason, and S. K. Frost-Mason. (1998). "Regulation of melanoblast migration and differentiation." Chapter 5 in The Pigmentary System: Physiology and Pathophysiology, J.J. Nordlund et al., eds. Oxford University Press: New York. pp. 75-95.M.V. Reedy, C. D. Faraco, and C. A. Erickson. (1998). The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube. Developmental Biology 200: 234-246.
M. V. Reedy, C. D. Faraco, and C. A. Erickson. (1998). Specification and migration of melanoblasts at the vagal level and in hyperpigmented Silkie chickens. Developmental Dynamics 213: 476-485.
C. A. Erickson and M. V. Reedy. (1998). Neural crest development: the interplay between morphogenesis and cell differentiation. Current Topics in Developmental Biology 40: 178-209.
R. Kos*, M. V. Reedy*, R. Johnson, and C.A. Erickson. (2001). The winged helix transcription factor cFoxD3 is important for establishing the neural crest lineage and repressing melanogenesis. Development 128: 1467-1479.
B.S. Kim, O.V. Savinova, M.V.Reedy, Y. Lun, L. Gan, S.I Tomarev, S.W.M. John, and R.L. Johnson. (2001) Targeted disruption of myocilin (MYOC) suggests that glaucoma-causing mutations of myocilin in humans are gain of function mutations. Molecular and Cellular Biology 21: 7707-7713.
M. V. Reedy, C. A. Erickson, and R. Johnson. (2003). The expression patterns of the receptor tyrosine kinase c-kit and its ligand, SCF, in chick embryos suggest unexpected roles in somite and limb development. Mechanisms of Development: Gene Expression Patterns, 3: 53-58.
D. G. Cole and M. V. Reedy. (2003). Algal morphogenesis: how Volvox turns itself inside-out. Current Biology, 13: R770-772.
B. J. Tierney, T. Ho, M. V. Reedy, and P. R. Brauer. (2004). Homocysteine inhibits neural crest cell formation and morphogenesis in vivo. Developmental Dynamics 229: 63-73.
V. Cantemir, D. H. Cai, M.V. Reedy, and P.R. Brauer. Tissue
inhibitor of metalloproteinase-2 (TIMP-2) expression during cardiac neural
crest cell migration and its role in proMMP-2 activation. Developmental
Dynamics, in press 07/04.
Last modified: March 21, 2007
