Ann Cavanaugh

Assistant Professor
Evolution and Formation of Protein Complexes

Ph.D. – University of California, Los Angeles, 2015
B.S. – Creighton University, 2008

Courses Offered

• BIO 362 – Cell Structure and Function

Research Interests

In the Cavanaugh lab we use two related species of yeast, S. cerevisiae, and K. lactis, to study the organization, dynamics, and evolution of the spindle pole body (SPB). The SPB is a microtubule organizing center and serves to organize and regulate the formation of the mitotic spindle in yeast. Although the function of the SPB is vitally important for yeast reproduction, the structure and composition of this large, multi-protein structure varies widely across the yeast phyla. By studying the SPB in two species of budding yeast we hope to uncover mechanisms by which individual proteins are able to co-evolve as part of a large protein structure.

Scholarly Works

Publications

Chen, J., Z. Xiong, D. E. Miller, Z. Yu, S. McCroskey, W. D. Bradford, A. M. Cavanaugh, and S. L. Jaspersen. 2020. The role of gene dosage in budding yeast centrosome scaling and spontaneous diploidization. PLoS Genetics 16:e1008911. DOI:10.1371/ JOURNAL.PGEN.1008911

Ziyad, S., J. D. Riordan, A. M. Cavanaugh, T. Su, G. E. Hernandez, G. Hilfenhaus, M. Morselli, K. Huynh, K. Wang, J.-N. Chen, A. J. Dupuy, and M. L. Iruela-Arispe. 2018. A forward genetic screen targeting the endothelium reveals a regulatory role for the lipid kinase Pi4ka in myelo- and erythropoiesis. Cell Reports 22:1211-1224. DOI:10.1016/j .celrep.2018.01.017

Cavanaugh, A. M., and S. L. Jaspersen. 2017. Big lessons from little yeast: Budding and fission yeast centrosome structure, duplication, and function. Annual Review of Genetics 51:361-383. DOI:10 .1146/annurev-genet-120116-024733

Cavanaugh, A. M., J. Huang, and J.-N. Chen. 2015. Two developmentally distinct populations of neural crest cells contribute to the zebrafish heart. Developmental Biology 404:103-112. DOI:10.1016/j. ydbio.2015.06.002

Patterson, R. A., A. M. Cavanaugh, V. Cantemir, P. R. Brauer, and M. V. Reedy. 2013. MT2-MMP expression during early avian morphogenesis. Anatomical Record 296:64-70. DOI:10.1002/ar.22618< /p>

Langenbacher, A. D., C. T. Nguyen, A. M. Cavanaugh, J. Huang, F. Lu, and J.-N. Chen. 2011. The PAF1 complex differentially regulates cardiomyocyte specification. Developmental Biology 353:19-28. DOI:10.1016/j. ydbio.2011.02.011

O'Brien, G. S., S. Rieger, S. M. Martin, A. M. Cavanaugh, C. Portera-Cailliau, and A. Sagasti. 2009. Two-photon axotomy and time-lapse confocal imaging in live zebrafish embryos. Journal of Visualized Experiments 24:e1129. DOI:10.3791/1129

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