Meeting Time: Tues/Thur 6:30-7:45pm
Course Location: Hixson-Lied Science Building RM 408
Instructor: Annemarie Shibata, Ph.D
Office Hours: Tuesday and Wednesday 9:00-11:00am and by appointment
Email: ash33271@creighton.edu
Course Website: http://biology.creighton.edu/courses/BIO432
Course Objectives
This lecture
course is designed to present the basic principles and concepts of immunology.
Topics such as organization of the immune system, evolution of the immune
system, and cellular and molecular mechanisms used by the immune system to
protect organisms from disease are discussed in detail. Additionally, course material examines
the practical application of immunological experimental advances in basic and
medical science.
Course Description
Introduction to Immunology is designed to
present a complete overview of the processes regulating the immune
response. Lecture material begins
with an overview of the immune system organization, cellular and organ
components and general function.
The evolution of the immune system is emphasized as students are
presented with the major scientific discoveries that have contributed to our
current understanding of the immune system. Students are introduced to the mechanisms of innate immunity
followed by a discussion of antibodies and antibody diversity, antigens, and
antigen-antibody interactions.
Following this introductory material, students are presented with a
discussion of adaptive immunity covering such topics as major histocompatibility complex
function, B and T cell development and differentiation, antigen recognition by B and T cell receptors,
generation of lymphocyte antigen receptors, antigen presentation to T
lymphocytes, and the development and survival of lymphocytes. Students are
presented with an introduction to cytokines and their role in regulation of
immune responses. The role of the
complement system and cell-mediated effector response conclude the middle
section of this course. The final
component of the course examines some of the roles of the immune system in
disease prevention with a focus on adaptive immunity to infection, vaccination,
and cancer immunology. The course
is ended with a discussion of consequences of abnormal immune responses. Students are introduced to such
concepts as the mechanisms for rejection of transplanted tissue and
autoimmunity.
Course Prerequisite
Biology 211 and
212, and one of the following courses, BIO 317, BIO 419, BIO 362, BIO 351, BIO
467
Text
The required
textbook for this course is Kuby Immunology, 5th
Edition, Goldsby, Kindt, Osborne, Kuby (2002). W.H.Freeman publisher.
Optional Text: Immunobiology, 5th
Edition. Janeway, Travers, Walport and Shlomchik (2001). Churchill Livingstone
publisher.
Attendance
I will not take
formal class attendance.
However, it is important for students to attend lecture since the
required text does not contain all material presented during lecture. It will be the student’s
responsibility to obtain any class notes missed due to an absence.
Additionally, unannounced quizzes will be given throughout the
semester (please see below). For
this reason, it is the student’s advantage to attend lecture and ask to
questions. While this is a
traditional lecture course, student participation is welcomed and encouraged.
Examinations and Quizzes
All examinations
are designed to assess the students’ understanding of material as
presented in the text, lecture, and any additional readings. Examinations
arecomprised of a combination of problem solving short answer, fill-in-the
blank, and modified K type
multiple choice. Accommodations
can be made for students with disabilities if scheduled with the faculty member
prior to the first examination.
In order to
encourage students to keep up with lecture and scheduled reading material, a
total of 50 points can be earned through short quizzes designed to assess a
basic understanding of recently covered course material. Six unannounced quizzes (10 points
each) will be given during the course.
The lowest quiz score will be dropped at the end of the semester. There are no make-up opportunities for missed quizzes.
Make-Up
Exams
You are expected
to take examinations at the scheduled time. If you must miss an examination, please contact me before
the day of the exam. Students who
do not give prior notice will be required to provide written documentation
verifying the reason for absence.
The make-up will be cumulative with emphasis placed on material covered
on missed exam. Make-up exams may
be taken during Finals Week.
|
Exams
1-3
100 points ea.
Quizzes
50 points
(5 X 10 points)
Final
Exam 150 points
Total
500 points
Unethical
behavior in this class will not be tolerated. The university policy as described in the Creighton
University Undergraduate Student Bulletin (2003-2004) directly applies to this
course. Academic dishonesty in the
form of cheating on examinations and/or plagerism on written work will result
in a total loss of points for that assignment or exam. Such loss of points may result in
failure of the course. A second offence, regardless of the number of points
lost, will result in automatic failure of the entire course. In the event of an incident of academic
dishonesty, the procedures of investigation and punishment that will be
followed can be found on the college web site at http://
puffin.creigton.edu/ccas/facstaff/polManual/polManual.htm.